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Updated: Aug 9, 2026
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Gene Transfer for Ischemic Heart Failure in a Preclinical Model
Published on: May 15, 2011
Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann
P W Christopherson1, T A Insalaco, V L van Santen
1Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Veterinary Pathology
|January 13, 2006
Abstract:
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.
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