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Related Experiment Videos

Double-blind, randomised, controlled trial assessing controller medications in asthma.

A R Shah1, L D Sharples, R N Solanki

  • 1Department of Chest Diseases, Civil Hospital, Ahmedabad, India. drashishshah@yahoo.com

Respiration; International Review of Thoracic Diseases
|January 13, 2006
PubMed
Summary
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Adding montelukast to budesonide significantly improved asthma control and lung function compared to high-dose budesonide or theophylline. This combination therapy offers a safe and effective option for managing inadequately controlled asthma.

Area of Science:

  • Pulmonology
  • Pharmacology
  • Clinical Medicine

Background:

  • Asthma management often requires optimizing controller medications.
  • Investigating add-on therapies aims to improve symptom control and reduce reliance on high-dose inhaled corticosteroids.

Purpose of the Study:

  • To compare the efficacy of adding montelukast or sustained-release theophylline to inhaled budesonide versus high-dose budesonide alone in patients with uncontrolled asthma.
  • To assess the impact on clinical symptoms and pulmonary function.

Main Methods:

  • A randomized, double-blind study involving 90 patients with incompletely controlled asthma.
  • Three groups: high-dose budesonide, budesonide plus theophylline, and budesonide plus montelukast.
  • Primary endpoints included forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate (PEFR).

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Main Results:

  • All treatment groups showed significant improvements in FEV1 and PEFR after 8 weeks.
  • Montelukast group demonstrated superior improvements in PEFR and FEV1 compared to both high-dose budesonide and theophylline groups.
  • Statistical significance was observed for all key comparisons.

Conclusions:

  • Montelukast, when added to budesonide, provides greater pulmonary function improvements than high-dose budesonide or theophylline.
  • This combination therapy is a safe and effective strategy for enhancing asthma control.
  • The findings support individualized treatment approaches in asthma management.