Related Experiment Video
Updated: Aug 13, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
"Flush-free niacin": dietary supplement may be "benefit-free"
1Pennsylvania Hospital of the University of Pennsylvania, Philadelphia, PA 19106, USA. rnorris@pennhearts.com
Abstract:
This report describes a patient with coronary artery disease who was instructed to take extended-release niacin to treat low high-density lipoprotein cholesterol and instead purchased "flush-free niacin" available at the pharmacy. There was no significant change in his lipids. Once the patient switched to extended-release niacin, the anticipated beneficial effects were seen. The article reviews the composition of flush-free niacin, its purported and real lipid effects, and warns against the effects of misleading marketing.
Related Concept Videos
Atherosclerosis III: Management
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Vitamins
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Coronary Artery Disease IV: Preventive Measures
