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Updated: Aug 13, 2026
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection
T W Orlikowsky1, C Trüg, F Neunhoeffer
1Department of Neonatology, University Children's Hospital, Tübingen, Germany.
Objectives:
To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI).
Study Design:
A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined.
Results:
LBP in the noninfected group increased until 24 h after birth (P < 0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r = 0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24-68) and 79% (54-94) vs 9 (0-24) and 39% (17-64); P < 0.05)), EOBI was most reliably detected by IL-8.
Conclusion:
LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI.
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