Opening the pore hinges on proline

Same author

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

bioRxiv : the preprint server for biology·2026

Same author

Discovery of Covalent Ligands with AlphaFold3.

Journal of the American Chemical Society·2026

Same author

Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.

Journal of the American Chemical Society·2025

Same author

Purification and characterization of full-length monomeric TEC family kinase, ITK.

Protein expression and purification·2025

Same author

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

eLife·2024

Same author

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.

Journal of medicinal chemistry·2024

Same journal

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Nature chemical biology·2026

Same journal

Artificial metalloenzymes in complex biological environments.

Nature chemical biology·2026

Same journal

Allosteric disordering of eIF2B regulates the integrated stress response.

Nature chemical biology·2026

Same journal

A tail of two ligases.

Nature chemical biology·2026

Same journal

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Nature chemical biology·2026

Same journal

Image-guided activation of drugs with electromagnetic radiation.

Nature chemical biology·2026

Related Experiment Videos

Opening the pore hinges on proline

Related Concept Videos

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

Discovery of Covalent Ligands with AlphaFold3.

Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.

Purification and characterization of full-length monomeric TEC family kinase, ITK.

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Artificial metalloenzymes in complex biological environments.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.

Related Experiment Videos

Opening the pore hinges on proline

Related Concept Videos

Related Articles

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

Discovery of Covalent Ligands with AlphaFold3.

Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.

Purification and characterization of full-length monomeric TEC family kinase, ITK.

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Artificial metalloenzymes in complex biological environments.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.