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Aging and humoral immunity
1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201.
Maryland Medical Journal (Baltimore, Md. : 1985)
|July 1, 1992
Abstract:
If human antibody responses undergo molecular shifts similar to those identified in mice, the appropriate immunization strategy for the elderly would be a passive administration of the protective antibody from young donors rather than an attempt to boost the individual's own response with a more potent vaccine, because the shifted immune system can no longer make the right kind of antibody.