Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane-associated GTPases in bacteria.

P E March1

  • 1Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.

Molecular Microbiology
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A biological assay for detection of heterogeneities in the surface hydrophobicity of polymer coatings exposed to the marine environment.

Biofouling·2011
Same author

Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function.

Molecular microbiology·2001
Same author

Alterations in the peptidyltransferase and decoding domains of ribosomal RNA suppress mutations in the elongation factor G gene.

RNA (New York, N.Y.)·2000
Same author

The function of conserved amino acid residues adjacent to the effector domain in elongation factor G.

Proteins·1999
Same author

Molecular genetics of bacterial attachment and biofouling.

Current opinion in biotechnology·1998
Same author

Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity.

Journal of bacteriology·1995

This review explores bacterial membrane-associated GTPases, crucial for cell signaling. While some resemble eukaryotic proteins, their specific functions and pathways remain largely unknown, highlighting a gap in understanding prokaryotic cell regulation.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Cell Biology

Background:

  • GTPases are vital regulators of membrane signaling pathways in all cells.
  • Prokaryotes possess unique membrane-associated GTPases with incompletely understood roles.

Purpose of the Study:

  • To review known prokaryotic membrane-associated GTPases.
  • To highlight similarities and differences with eukaryotic counterparts.
  • To identify gaps in understanding their signaling pathways.

Main Methods:

  • Literature review of prokaryotic GTPases.
  • Sequence homology analysis.
  • Comparison with eukaryotic GTPase families.

Main Results:

  • Identified bacterial GTPases LepA, NodQ, FtsY, Ffh, Obg, and Era.

Related Experiment Videos

  • LepA and NodQ show similarity to protein synthesis factors but have membrane functions.
  • FtsY and Ffh relate to eukaryotic protein secretion factors.
  • Obg and Era are essential but lack clear GTPase subgroup relation.
  • Signaling pathways are elucidated for most, except NodQ.

    • Conclusions:

    • Prokaryotic membrane-associated GTPases represent a diverse group with essential cellular roles.
    • Functional and pathway elucidation is needed for most bacterial GTPases, despite sequence similarities to known eukaryotic proteins.