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Related Experiment Videos

Diffusion tensor imaging abnormalities in focal cortical dysplasia.

Donald W Gross1, Alexandre Bastos, Christian Beaulieu

  • 1Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|January 18, 2006
PubMed
Summary

Diffusion tensor imaging (DTI) detects white matter changes in focal cortical dysplasia (FCD) with visible abnormalities. However, DTI did not identify abnormalities in FCD lesions with normal-appearing white matter on conventional MRI.

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Focal cortical dysplasia (FCD) is a common cause of intractable epilepsy.
  • Conventional MRI may not detect all FCD lesions.
  • Diffusion tensor imaging (DTI) shows promise for detecting FCD.

Purpose of the Study:

  • To investigate subcortical white matter abnormalities in FCD using DTI.
  • To assess DTI's sensitivity in detecting FCD lesions.

Main Methods:

  • Acquired DTI images in five epilepsy patients with FCD.
  • Calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) maps.
  • Compared subcortical white matter ipsilateral and contralateral to lesions.

Main Results:

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  • DTI showed increased ADC and reduced FA in FCD with white matter hyperintensities.
  • Increased perpendicular diffusivity was noted in these cases.
  • No DTI abnormalities were found in FCD without visible white matter changes.

Conclusions:

  • DTI abnormalities correlate with micro-structural degradation in FCD with white matter involvement.
  • DTI did not detect abnormalities in FCD lesions with normal-appearing white matter.