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Updated: Aug 13, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Prognostic indicators in an aggressive pituitary Crooke's cell adenoma
Objective:
To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary.
Methods:
The surgically removed tumor was studied by histology, immunohistochemistry and transmission electron microscopy.
Results:
An aggressive invasive sellar tumor removed by repeated surgeries from a 43-year-old woman with pituitary related Cushing's disease was classified as a Crooke's cell adenoma of the pituitary. The application of several cell proliferation markers confirmed the aggressive nature of the tumor.
Conclusions:
The investigation of the present case provides additional evidence that pituitary Crooke's cell adenomas may possess aggressive behavior.