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Published on: February 19, 2019
[Local cytokine levels and morphological parameters in chronic viral hepatitis C]
Abstract:
The association of the level of local cytokines, such as interleukin (IL)-1alpha, IL-2, IL-4, tumor necrosis factor-alpha (TNF-alpha), and gamma-interferon (gamma-INF) was studied in the liver biopsy specimens from patients with chronic hepatitis C (CHC) with clinical and morphological indices and biochemical and virological findings. There was a polymorphism of clinical symptoms, as well as extrahepatic manifestations in the group that had significantly elevated levels of IL-1alpha, IL-4, and TNF-alpha, as well as decreased concentrations of IL-2 and gamma-INF. The activity of necrotic inflammatory manifestations in the liver in CHC is also associated with a more pronounced shift towards an increase in the levels of IL-1alpha, IL-4, and TNF-alpha, and a decrease in those of IL-2 and gamma-INF.
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