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Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds
Saïd Yous1, Nicolas Lebegue, Jacques-Henry Poupaert
1Laboratoire de Chimie Thérapeutique, EA 1043, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Professeur Laguesse, B. P. 83 59006, Lille Cedex, France.
Abstract:
Fifteen compounds derived from the 2(3H)-benzothiazolone template with an acyl side-chain in position-6 were evaluated for their lipid-lowering action in mice. Among these compounds, 6-benzoyl-2(3H)-benzothiazolone was found to be the most potent one both in mice models receiving a hypercholesterolemic diet (for 15 days) or a standard diet (for 21 days). 6-Benzoyl-2(3H)-benzothiazolone compares favorably with fenofibrate, the standard drug, both in terms of HDL-C/Chol (High Density Lipoprotein-Cholesterol/Total Cholesterol) ratio and absence of liver hepatomegaly.
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