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Updated: Aug 13, 2026
An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants
Published on: June 12, 2026
[Alkaloids from the root of Lindera angustifolia]
Qi-Zhi Zhao1, Yi-Min Zhao, Ke-Jun Wang
1Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China.
Aim:
To study the alkaloid constituents of the root of Lindera angustifolia Cheng.
Methods:
The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis.
Results:
Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV), norboldine (V), N-ethoxycarbonyllaurotetanine (VII) and a quaternary isoquinoline alkaloid, magnocurarine (VI), were isolated and identified. The structure of VII was further identified by semi-synthesis with I as starting material.
Conclusion:
All compounds were obtained from this plant for the first time and compound VII was found as a naturally occurring compound for the first time.
