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Adsorption of meloxicam on porous calcium silicate: characterization and tablet formulation

Sameer Sharma1, Praveen Sher, Shraddha Badve

  • 1Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandawane, Pune-411038, Maharashtra State, India.

AAPS Pharmscitech
|January 18, 2006
PubMed

Insights

This study developed meloxicam microparticles using Florite RE (FLR) for improved drug dissolution. Tablets formulated with these microparticles exhibited faster disintegration and enhanced dissolution compared to commercial products.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Poorly water-soluble drugs present formulation challenges impacting bioavailability.
  • Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) with limited aqueous solubility.
  • Developing advanced drug delivery systems is crucial for improving therapeutic efficacy.

Purpose of the Study:

  • To characterize meloxicam-adsorbed porous silicate carrier (Florite RE) microparticles.
  • To develop directly compressible tablets using these microparticles.
  • To evaluate the improved drug dissolution properties and pharmaceutical utility of Florite RE.

Main Methods:

  • Meloxicam adsorption onto Florite RE (FLR) at 1:1 and 1:3 ratios via solvent evaporation.
  • Characterization of microparticles: surface topography, thermal analysis, XRD, FTIR, residual solvent, micromeritics, drug content, solubility, and dissolution.
  • Formulation of directly compressible tablets and comparison with a commercial product.

Main Results:

  • Meloxicam-adsorbed FLR microparticles exhibited bulk density between 0.10-0.12 g/cm³.
  • A 1:3 drug:FLR ratio demonstrated faster drug dissolution than a 1:1 ratio.
  • Prepared tablets showed acceptable mechanical properties, faster disintegration (18-38s), and significantly improved dissolution in acidic and basic media compared to commercial tablets.

Conclusions:

  • Florite RE serves as an effective pharmaceutical excipient for enhancing drug dissolution.
  • Increased surface area and reduced drug crystallinity of meloxicam adsorbed on FLR contribute to improved dissolution.
  • The developed microparticle-based tablets offer a promising approach for formulating poorly soluble drugs with enhanced bioavailability.

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