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Updated: Aug 13, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Carbohydrate-derived amino-alcohol ligands for asymmetric alkynylation of aldehydes
Daniel P G Emmerson1, William P Hems, Benjamin G Davis
1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK.
Abstract:
[reaction: see text] Conformationally restricted amino alcohols based on carbohydrate scaffolds provide flexible and fine-tuneable libraries that greatly expand the range of ligands available in the Zn(OTf)(2)-mediated addition of alkynes to aldehydes, in some cases with very high stereoselectivities.
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