Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Erythrocyte structure and dynamics quantified by Hilbert phase microscopy.

Gabriel Popescu, Takahiro Ikeda, Catherine A Best

    Journal of Biomedical Optics
    |January 18, 2006
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Collateral damage from violent incidents: human costs of polio immunization.

    Bulletin of the World Health Organization·2025
    Same author

    Tracing chalcolithic population mobility using strontium isotopes and proteomics at Gumelnița site, Romania.

    Scientific reports·2025
    Same author

    Characterization of environmental and clinical surveillance inputs to support prospective integrated modeling of the polio endgame.

    PLOS global public health·2025
    Same author

    Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.

    Journal of biomedical optics·2024
    Same author

    Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.

    Journal of biomedical optics·2024
    Same author

    Review of Poliovirus Transmission and Economic Modeling to Support Global Polio Eradication: 2020-2024.

    Pathogens (Basel, Switzerland)·2024

    We developed a new method to study red blood cell shape and movement. This technique noninvasively quantifies cell volume and dynamic morphology, offering insights into erythrocyte health.

    Area of Science:

    • Biophysics
    • Hematology
    • Microscopy

    Background:

    • Red blood cell (erythrocyte) morphology and dynamics are crucial for oxygen transport.
    • Noninvasive methods for studying live erythrocytes are needed to understand their health and function.

    Purpose of the Study:

    • To present a novel quantitative method for investigating red blood cell morphology and dynamics.
    • To demonstrate the noninvasive assessment of live erythrocytes using integrated microscopy techniques.

    Main Methods:

    • Integration of quantitative phase microscopy with an inverted microscope.
    • Development of a system with subnanometer path-length sensitivity at millisecond time scales.
    • Application of the method for noninvasive quantification of cell volume and dynamic morphology.

    Related Experiment Videos

    Main Results:

    • The instrument allows for noninvasive assessment of live erythrocytes.
    • Quantification of cell volume and dynamic morphology was successfully demonstrated.
    • Hemoglobin flow out of the cell during hemolysis was measured, showcasing the system's sensitivity.

    Conclusions:

    • The presented quantitative method offers a powerful tool for studying red blood cell behavior.
    • This technique facilitates noninvasive, high-sensitivity analysis of erythrocyte dynamics.
    • The approach has potential applications in hematology research and diagnostics.