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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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Related Experiment Video

Updated: Jun 23, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Angiogenesis.

Judah Folkman1

  • 1Vascular Biology Program, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115-5737, USA. judah.folkman@childrens.harvard.edu

Annual Review of Medicine
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Approved angiogenesis inhibitors offer broad anticancer activity with minimal side effects. This novel drug class, informed by angiogenesis research, presents a promising approach to treating drug resistance.

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Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Angiogenesis is crucial for tumor growth and expansion.
  • Approved angiogenesis inhibitors have broad anticancer activity and minimal side effects.
  • Endogenous angiogenesis inhibitors function as tumor suppressor proteins.

Purpose of the Study:

  • To review the clinical application of angiogenesis inhibitors in cancer treatment.
  • To discuss the principles of angiogenesis research informing drug development.
  • To introduce antiangiogenic chemotherapy as a novel approach to overcome drug resistance.

Main Methods:

  • Review of clinical trial data and regulatory approvals.
  • Analysis of preclinical research on angiogenesis inhibitors.
  • Synthesis of information on endogenous angiogenesis inhibitors and host genetic factors.

Main Results:

  • Angiogenesis inhibitors are approved globally, including in the US and China.
  • Two broad-spectrum angiogenesis inhibitors with minimal side effects have been developed.
  • Angiogenic response is influenced by host genetic background.
  • Some angiogenesis inhibitors exhibit a U-shaped efficacy curve.

Conclusions:

  • Angiogenesis inhibitors represent a significant advancement in cancer therapy.
  • Understanding angiogenesis mechanisms is key to developing effective cancer treatments.
  • Antiangiogenic chemotherapy offers a new strategy for managing drug-resistant cancers.