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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 19, 2013

Chemoprevention of prostate cancer

Eric A Klein1

  • 1Section of Urologic Oncology, Glickman Urological Institute and Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. kleine@ccf.org

Annual Review of Medicine
|January 18, 2006
PubMed

Insights

Chemoprevention can prevent prostate cancer using oral agents. However, current evidence is insufficient to recommend dietary supplements for routine prostate cancer prevention.

Area of Science:

  • Oncology
  • Preventive Medicine
  • Molecular Pathogenesis

Background:

  • Prostate cancer is a common malignancy with a long latency period.
  • Chemoprevention is a promising strategy due to the cancer's molecularly defined pathogenesis and treatment morbidities.

Purpose of the Study:

  • To review the evidence for prostate cancer chemoprevention.
  • To assess the role of oral agents and supplements in preventing prostate cancer.

Main Methods:

  • Review of findings from the Prostate Cancer Prevention Trial.
  • Discussion of ongoing and planned clinical trials for chemopreventive agents.
  • Evaluation of the evidence for antioxidants and antiandrogenic compounds.

Main Results:

  • The Prostate Cancer Prevention Trial demonstrated that prostate cancer can be prevented by a non-toxic oral agent.
  • Several agents, including antioxidants with antiandrogenic properties, are under investigation in large clinical trials.

Conclusions:

  • Chemoprevention is a viable strategy for prostate cancer.
  • Current evidence does not support routine recommendations for dietary or nutritional supplements for prostate cancer prevention.

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