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Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older

N S Jenny1, A M Arnold, L H Kuller

  • 1Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA.

Journal of Thrombosis and Haemostasis : JTH
|January 18, 2006
PubMed

Insights

Soluble intercellular adhesion molecule-1 (sICAM-1) is linked to increased mortality risk in older adults. This cardiovascular disease marker showed a stronger association with cardiovascular death in women than in men.

Area of Science:

  • Cardiovascular Science
  • Biomarker Research
  • Gerontology

Background:

  • Intracellular adhesion molecule-1 (ICAM-1) plays a role in leukocyte-endothelial attachment, a key process in atherosclerosis development.
  • Circulating soluble ICAM-1 (sICAM-1) is being investigated as a potential biomarker for cardiovascular disease (CVD) progression.

Purpose of the Study:

  • To investigate the association between sICAM-1 levels and subclinical CVD measures.
  • To assess the risk of incident CVD events and death associated with sICAM-1 in older adults.

Main Methods:

  • Analysis of older men and women (age >= 65) from the Cardiovascular Health Study, free of clinical CVD at baseline.
  • Incident cases included angina, myocardial infarction, stroke, and death (including CVD death).
  • Cox regression models were used to analyze associations, adjusting for age, gender, and race.

Main Results:

  • sICAM-1 correlated positively with inflammatory markers (C-reactive protein, interleukin-6, fibrinogen) and subclinical CVD.
  • Elevated sICAM-1 levels were associated with increased all-cause mortality risk in both men and women.
  • A stronger association was observed between sICAM-1 and cardiovascular death in women compared to men.

Conclusions:

  • sICAM-1 is associated with increased mortality in older populations.
  • The association between sICAM-1 and cardiovascular death is more pronounced in women.
  • sICAM-1 may serve as a valuable prognostic marker for cardiovascular outcomes in older adults, particularly women.
Abstract

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