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[The relationship between the five beta-fibrinogen gene polymorphisms and cerebral infarction]
1Department of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Zhonghua Nei Ke Za Zhi
|January 18, 2006
Summary
Elevated beta-fibrinogen (Fg) levels are a risk factor for cerebral infarction. Specific alleles, T-148 and A-455, are associated with higher Fg concentrations, contributing to this risk.
Area of Science:
- Biochemistry
- Genetics
- Neurology
Context:
- Cerebral infarction is a significant cause of mortality and morbidity worldwide.
- Fibrinogen (Fg) is a key protein in blood coagulation, and its elevated levels have been implicated in thrombotic events.
Purpose:
- To examine the association between beta-fibrinogen (Fg) concentration, specific Fg gene polymorphisms (-148C/T, -249C/T, -455G/A, 448G/A, 1689T/G), and the risk of cerebral infarction.
- To determine if Fg gene variations influence Fg levels and contribute to cerebral infarction susceptibility.
Summary:
- Plasma Fg levels were significantly higher in cerebral infarction patients compared to controls.
- Individuals with T-148 and A-455 alleles exhibited higher plasma Fg levels across all groups.
- No significant differences in genotype or allele frequencies of the studied Fg polymorphisms were observed among the groups.
Impact:
- This study identifies elevated Fg levels as a risk factor for cerebral infarction.
- The T-148 and A-455 alleles are linked to increased Fg concentration, potentially influencing thrombotic risk.
- Findings contribute to understanding the multifactorial nature of cerebral infarction and may inform future risk assessment strategies.
