Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammation following stroke.

M Nilupul Perera1, Henry K Ma, Shuji Arakawa

  • 1National Stroke Research Institute, Austin Health, University of Melbourne, Level 1, Neurosciences Building, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia. nilupulperera@yahoo.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Impact of plasma pTau181 levels on clinician diagnostic confidence and management in memory and cognition clinics: A multi-site before-and-after study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.

GeroScience·2026
Same author

Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.

EBioMedicine·2026
Same author

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Genetic variation in the glymphatic pathway predicts cognition and neurodegeneration in preclinical Alzheimer's disease.

Research square·2026
Same journal

Tumor control and cranial nerve outcomes after Gamma Knife radiosurgery for Glomus jugulare tumors: a systematic review, meta-analysis, and institutional failure pattern analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Clinical utility of maximal and minimal intensity projections in T2-weighted MRI for neurosurgical planning.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Clinical and CT perfusion outcomes after direct STA-MCA bypass in moyamoya and non-moyamoya steno-occlusive disease: an Indonesian single-center cohort.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Effect of non-consecutive treatment during hypofractionated stereotactic radiosurgery (HF-SRS) for brain metastases.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Pre- and postoperative cranial shape analysis in Craniosynostosis: The role of mechanical loading during CT imaging.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Spontaneous Recanalization of Thrombus on Ultra-High field Strength MRI.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
See all related articles

Inflammation suppression shows promise in animal stroke models, reducing damage and improving outcomes even beyond typical treatment times. Further understanding of these anti-inflammatory mechanisms is crucial for stroke treatment.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Medicine

Background:

  • Stroke is a major cause of death and disability worldwide.
  • Inflammation plays a significant role in stroke pathology, persisting for months.
  • Current treatments like thrombolysis have limited time windows.

Purpose of the Study:

  • To investigate the potential of anti-inflammatory strategies in stroke treatment.
  • To explore if suppressing inflammation can improve outcomes in various stroke models.
  • To determine if anti-inflammatory agents can extend the therapeutic window for existing stroke therapies.

Main Methods:

  • Utilizing various drugs to suppress inflammation in animal models of stroke.
  • Assessing the impact of anti-inflammatory therapy on infarct volume.

Related Experiment Videos

  • Evaluating treatment initiation beyond the standard 3-hour window for thrombolysis.
  • Examining effects in both ischemic and hemorrhagic stroke models.

    • Main Results:

    • Suppression of inflammation reduced infarct volume in animal models.
    • Therapeutic benefits were observed even when treatment started after 3 hours.
    • Anti-inflammatory approaches showed potential in hemorrhagic stroke models.
    • Clinical trials with anti-inflammatory agents in acute ischemic stroke have not yet shown improved outcomes.

    Conclusions:

    • Anti-inflammatory strategies hold significant therapeutic potential for stroke, applicable to both ischemic and hemorrhagic types.
    • Understanding anti-inflammatory mechanisms is key to developing broader stroke treatments.
    • Further research is needed to translate promising animal model findings into effective clinical therapies for stroke patients.