Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testosterone improves motor function in Parkinson's disease.

E Mitchell1, D Thomas, R Burnet

  • 1Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, 5000, South Australia, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|January 18, 2006
PubMed
Summary

Testosterone therapy may improve motor symptoms in Parkinson's disease (PD) patients with testosterone deficiency. This case report shows improved tremor and motor control after testosterone administration, correlating with increased hormone levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Team nursing.

Nursing times·1992
Same author

Lack of platelet-activating factor release during reversible myocardial ischaemia.

European heart journal·1992
Same author

[Diagnostic and therapeutic strategy in patients with multiple arterial disease].

Annales de cardiologie et d'angeiologie·1992
Same author

Risk assessment for aflatoxin B1: a modeling approach.

Risk analysis : an official publication of the Society for Risk Analysis·1992
Same author

Comparison of skin changes induced on mice by either group A type 12 or group G streptococci.

Experimental dermatology·1992
Same author

IBIS integrated biological imaging system: electron micrograph image-processing software running on Unix workstations.

Computer applications in the biosciences : CABIOS·1992

Area of Science:

  • Neuroendocrinology
  • Movement Disorders

Background:

  • Parkinson's disease (PD) involves nigrostriatal pathways, modulated by sex steroids like testosterone.
  • Testosterone deficiency is prevalent in older men and PD patients, impacting non-motor symptoms.

Observation:

  • A case report details a Parkinson's patient with severe testosterone deficiency (1 nmol/L).
  • The patient experienced significant improvements in resting tremor and fine motor control.

Findings:

  • Motor symptom improvements, including handwriting and tremor amplitude, were observed after testosterone administration.
  • Enhanced motor function correlated directly with increased serum testosterone levels.
  • Unified Parkinson's Disease Rating Scale (UPDRS) self-reporting indicated improvement.

Related Experiment Videos

Implications:

  • Testosterone replacement therapy may benefit motor symptoms in testosterone-deficient PD patients.
  • This approach could enhance overall well-being in affected individuals.
  • Further research into testosterone's role in PD motor function is warranted.