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Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy
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Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy

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The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation

Melanie Gerard1, Zeger Debyser, Linda Desender

  • 1Laboratory of Biomolecular Dynamics, K.U. Leuven, Leuven, Belgium.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|January 18, 2006
PubMed

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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