Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TLR signaling.

T Kawai1, S Akira

  • 1Exploratory Research for Advanced Technology, Japan Science and Technology Agency, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Cell Death and Differentiation
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toll-Like Receptors-Intrarenal Mechanisms beyond Immune Function: Renal-Associated TLR2 Mediates Ischemia/Reperfusion Injury in the Kidney.

Journal of the American Society of Nephrology : JASN·2023
Same author

Activation of innate immunity by 14-3-3 ε, a new potential alarmin in osteoarthritis.

Osteoarthritis and cartilage·2020
Same author

Low-dose gonadotropin-releasing hormone agonist therapy (draw-back therapy) for successful long-term management of adenomyosis associated with cerebral venous and sinus thrombosis from low-dose oral contraceptive use.

Clinical and experimental obstetrics & gynecology·2018
Same author

Hybrid Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse With Severe Cystocele.

Journal of minimally invasive gynecology·2016
Same author

Surgical Treatment Outcomes in Patients With Recurrent Pregnancy Loss Attributed to Septate Uterus.

Journal of minimally invasive gynecology·2016
Same author

An Easy and Safe Approach to the Minimally Invasive Laparoscopic Treatment of Dermoid Cysts: The Mimic Laparoscopic Surgery With Bathtub Method.

Journal of minimally invasive gynecology·2016
Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026
Same journal

SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice.

Cell death and differentiation·2026
Same journal

LFPM inhibition of RING1-mediated p53<sup>R175H</sup> degradation drives oncogenesis in p53<sup>R175H</sup>-mutant cancers.

Cell death and differentiation·2026
Same journal

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer.

Cell death and differentiation·2026
Same journal

Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson's disease.

Cell death and differentiation·2026
See all related articles

Toll-like receptors (TLRs) are crucial for innate immunity, recognizing pathogens and initiating adaptive responses. This review details TLR signaling pathways and explores emerging TLR-independent pathogen recognition mechanisms.

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Toll-like receptors (TLRs) are key mediators of innate immunity.
  • TLRs recognize conserved molecular patterns on pathogens like bacteria and viruses.
  • Activation of TLRs triggers inflammatory and antiviral responses, crucial for pathogen eradication.

Purpose of the Study:

  • To review recent advances in understanding Toll-like receptor (TLR) signaling pathways.
  • To elucidate the role of TLRs in orchestrating innate and adaptive immune responses.
  • To discuss novel TLR-independent mechanisms for microbial pathogen recognition.

Main Methods:

  • Literature review of recent research on TLR signaling.
  • Analysis of molecular interactions between TLRs, adapter proteins, and transcription factors.

Related Experiment Videos

  • Synthesis of current knowledge on TLR-dependent and -independent immune activation.

    • Main Results:

    • TLRs activate specific transcription factors like NF-kappaB, AP-1, and IRFs.
    • TLR signaling leads to dendritic cell maturation and pathogen clearance.
    • Emerging evidence suggests TLR-independent pathways contribute to pathogen recognition.

    Conclusions:

    • TLR signaling pathways are complex and diverse, dictating specific immune outcomes.
    • Understanding TLRs is vital for developing new immunotherapies.
    • TLR-independent recognition mechanisms represent a significant area for future research.