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Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII

Sam Schulman1, Geir E Tjønnfjord, Richard Wallensten

  • 1Coagulation Unit, Department of Haematology, Karolinska University Hospital, Stockholm, Sweden. schulms@mcmaster.ca

Thrombosis and Haemostasis
|January 18, 2006
PubMed

The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical procedures in 7 patients with congenital FVII deficiency are reported here. rFVIIa was always given in continuous infusion,aiming at plasma FVII activity of 0.5 IU/mL. Treatment was given for 2 to 7 days with a mean total dose of 7.8 mg rFVIIa. Blood loss was as expected from the different types of procedures and the only thromboembolic complication was a superficial thrombophlebitis at the infusion site. This mode of substitution was therefore safe, effective and well tolerated.

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