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Related Experiment Videos

Elevated plasma glucagon in amyotrophic lateral sclerosis.

R W Hubbard1, A D Will, G W Peterson

  • 1Department of Pathology, Loma Linda University, Schools of Medicine, CA.

Neurology
|August 1, 1992
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) patients exhibit abnormal glucagon levels, potentially explaining glucose intolerance and altered insulin responses. This study investigated glucagon and insulin changes after soy or casein meals in ALS.

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Area of Science:

  • Endocrinology
  • Neurodegenerative Diseases
  • Metabolic Research

Background:

  • Amyotrophic lateral sclerosis (ALS) is associated with metabolic dysregulation, including glucose intolerance and abnormal plasma amino acid levels.
  • Altered glucagon secretion may contribute to the observed metabolic abnormalities in ALS patients.

Purpose of the Study:

  • To investigate the role of glucagon abnormalities in glucose intolerance and insulin reactions in ALS.
  • To compare the effects of different protein sources (soy vs. casein) on glucagon, insulin, and glucose levels in ALS patients.

Main Methods:

  • Eleven ALS patients received two test meals (soy or casein) on separate occasions.
  • Fasting and postprandial blood samples were collected to measure glucagon, insulin, and glucose levels.

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  • Data were compared between ALS patients and control subjects.

    • Main Results:

    • Elevated fasting and postprandial glucagon levels were observed in ALS patients compared to controls after both soy and casein meals (p < 0.01).
    • Insulin levels were elevated in response to both test meals in ALS patients.
    • The casein test meal significantly worsened glucose intolerance in ALS patients.

    Conclusions:

    • Abnormalities in glucagon regulation are present in ALS patients and may contribute to metabolic disturbances.
    • Dietary protein source influences metabolic responses in ALS, with casein exacerbating glucose intolerance.