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Recognition of secondary structures in proteins by a diiron(III) complex via a hydrolytic pathway
Qunhui Pan1, Wei Jiang, Zhanru Liao
1Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
Abstract:
The diiron(III) complex Fe(2)(DTPB)(mu(2)-O)(mu(2)-OAc)Cl(BF(4))(2) [DTPB = 1,1,4,7,7-pentakis(2'-benzimidazol-2-yl-methyl)triazaheptane, OAc = acetate] exhibits a similar affinity for proteins belonging to different structural patterns. However, this diiron complex is sensitive to secondary structures in a protein when it is used to promote the protein hydrolysis, indicating that some metal complexes, such as artificial proteolytic agents, could become a new hydrolytic probe of protein structures.
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