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Incidence and etiology of ischemic stroke in Persian young adults

K Ghandehari1, Z Izadi Moud

  • 1Neurology Division, Southern Khorasan University of Medical Sciences, Southern Khorasan, Iran. kavianghandehari@yahoo.com

Acta Neurologica Scandinavica
|January 18, 2006
PubMed

Insights

Rheumatic valvular disease is the most common cause of ischemic stroke in young adults in Iran. Early detection and treatment can prevent a significant number of these strokes.

Area of Science:

  • Neurology
  • Cardiology
  • Public Health

Background:

  • Stroke in young adults leads to significant morbidity in a crucial socioeconomic demographic.
  • The causes of ischemic stroke vary globally in this age group.

Purpose of the Study:

  • To investigate the etiologic frequency of ischemic stroke in young adults in Southern Khorasan, Iran.
  • To identify the most common causes and preventable factors of stroke in this population.

Main Methods:

  • A prospective study of 124 patients aged 15-45 years with ischemic stroke from March 2000 to March 2005.
  • Data collected included demographics, clinical presentation, and diagnostic investigations.
  • Etiologic classification followed the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria.

Main Results:

  • The incidence of ischemic stroke in young adults was 8 per 100,000 person-years.
  • Cardioembolic mechanisms accounted for 54% of stroke etiologies.
  • Rheumatic valvular disease was identified in 32% of patients, causing 2.5 preventable strokes per 100,000 young adults annually.

Conclusions:

  • Rheumatic valvular disease is the primary cause of stroke in young Persian adults.
  • This etiology is preventable, highlighting the need for targeted public health interventions.
Abstract

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