Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How does fish oil lower plasma triglycerides?

J G Coniglio1

  • 1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232.

Nutrition Reviews
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Testicular lipids.

Progress in lipid research·1994
Same author

Free fatty acids in plasma may exert feed-back control of lipoprotein lipase activity.

Nutrition reviews·1993
Same author

The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates.

Journal of pediatric gastroenterology and nutrition·1991
Same author

Biosynthesis of [14C]arachidonic acid from [14C]linoleate in primary cultures of rat Sertoli cells.

Lipids·1989
Same author

Effect of hypophysectomy and hormone replacement on fatty elongation in isolated microsomes of rat testes.

Archives of andrology·1988
Same author

The effects of streptozotocin diabetes and of dietary protein content on the composition and metabolism of testicular lipids.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·1984
Same journal

Natural Approaches to Appetite Suppression in Obesity: Mechanisms, Evidence, and Clinical Integration.

Nutrition reviews·2026
Same journal

The Effect of Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Neuromuscular Function in Humans: A Systematic Review with Narrative Synthesis.

Nutrition reviews·2026
Same journal

Oats in Gluten-Free Diets: An Examination of the Codex Standard and Country-Specific Differences in Gluten-Free-Food Labeling Regulations, for Oats and Oats Declared as Ingredients in Gluten-Free Products.

Nutrition reviews·2026
Same journal

Ultra-Processed Foods and Health Outcomes in Children and Adults: An Updated Narrative Umbrella Review With a Focus on Dose-Response.

Nutrition reviews·2026
Same journal

A Scoping Review of Nutritional Guidelines and Practices in Day Care Centers.

Nutrition reviews·2026
Same journal

Time-Restricted Feeding/Eating and Muscle Aging: Research Progress from Molecular Mechanisms to Personalized Intervention Strategies.

Nutrition reviews·2026
See all related articles

Dietary fish oil lowers plasma triacylglycerol by reducing liver phosphatidate hydrolysis. This impacts microsomal synthesis of triacylglycerol from diacylglycerol.

Area of Science:

  • Biochemistry
  • Nutrition Science
  • Lipid Metabolism

Background:

  • Elevated plasma triacylglycerol is a risk factor for cardiovascular disease.
  • Dietary lipids significantly influence lipid metabolism and plasma triacylglycerol levels.
  • Fish oil, safflower oil, and palm oil have distinct effects on lipid profiles.

Purpose of the Study:

  • To investigate the mechanism by which dietary fish oil reduces plasma triacylglycerol.
  • To explore the role of liver phosphatidate hydrolysis in fish oil-induced triacylglycerol reduction.
  • To understand the impact on microsomal triacylglycerol synthesis.

Main Methods:

  • Comparative analysis of dietary interventions using fish oil, safflower oil, and palm oil.
  • Measurement of plasma triacylglycerol levels.

Related Experiment Videos

  • Assessment of hepatic phosphatidate hydrolysis capacity.
  • Evaluation of microsomal triacylglycerol synthesis from diacylglycerol.

    • Main Results:

    • Dietary fish oil significantly decreased plasma triacylglycerol compared to safflower and palm oils.
    • A reduction in the liver's capacity to hydrolyze phosphatidate was observed with fish oil intake.
    • This decreased phosphatidate hydrolysis was correlated with altered microsomal triacylglycerol synthesis.

    Conclusions:

    • Dietary fish oil exerts its plasma triacylglycerol-lowering effect by inhibiting hepatic phosphatidate hydrolysis.
    • The observed effect on phosphatidate hydrolysis subsequently influences the microsomal synthesis pathway of triacylglycerol.
    • Understanding these mechanisms provides insight into dietary strategies for managing hypertriglyceridemia.