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Cellular retinol-binding protein functions in the regulation of retinoid metabolism
1Department of Nutritional Sciences, University of California, Berkeley 94720.
Nutrition Reviews
|July 1, 1992
Abstract:
A microsomal retinyl ester hydrolase from rat tissues is activated by apo-cellular retinol-binding protein, which thus regulates the availability of retinol either for binding to serum retinol-binding protein or for metabolic oxidation. Microsomal retinal synthesis was found to occur in rat tissues with holo-cellular retinol-binding protein as substrate. Retinal could be further oxidized to retinoic acid by a cytosolic fraction.