A novel series of urea-based peptidomimetic calpain inhibitors
M Lee Sanders1, Isaac O Donkor
1Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Bioorganic & Medicinal Chemistry Letters
|January 18, 2006
Abstract:
A series of peptide aldehyde derivatives in which the P(2) chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of mu-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for mu-calpain over cathepsin B.
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