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A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties
Mahesh Subramanian1, Ramesh Chander, Subrata Chattopadhyay
1Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Abstract:
The DNA targeting and membrane damaging activities of a novel tripyrrole 1 obtained as a red pigment from the Micrococcus sp. were investigated. It was found that compound 1 binds with DNA efficiently and facilitates copper-mediated DNA cleavage as well as peroxidation of membrane lipids by a process that does not require any external reducing agent. Compound 1 also showed impressive cytotoxicity to both mouse and human tumour cell lines. The membrane damaging ability of compound 1 might be vital in its nuclease and cytotoxicity properties. Interestingly, compared to the various DNA cleaving agents, compound 1 showed a preferential binding with the G-C rich domain.
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