Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is there compensated hypothyroidism in infancy?

R Alemzadeh1, S Friedman, P Fort

  • 1Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, NY.

Pediatrics
|August 1, 1992
PubMed
Summary

Newborn screening can identify infants with high thyroid-stimulating hormone (TSH) but normal thyroxine (T4) levels. Measuring basal metabolic rate (BMR) helps detect subclinical hypothyroidism in these infants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body composition analysis by dual-energy X-ray absorptiometry in young preschool children.

European journal of clinical nutrition·2016
Same author

High chlorpyrifos resistance in Culex pipiens mosquitoes: strong synergy between resistance genes.

Heredity·2015
Same author

Animal models of REM dysfunctions: what they tell us about the cause of narcolepsy and RBD?

Archives italiennes de biologie·2015
Same author

Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units.

Early human development·2012
Same author

New adolescent polycystic ovary syndrome perspectives.

Minerva pediatrica·2011
Same author

MiniSOX9, a dominant-negative variant in colon cancer cells.

Oncogene·2011

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Screening
  • Metabolic Studies

Background:

  • Newborn screening programs identify infants with potential thyroid dysfunction.
  • Some infants present with elevated thyroid-stimulating hormone (TSH) but normal thyroxine (T4) levels, a condition requiring further investigation.
  • The clinical significance of isolated hyperthyrotropinemia in neonates is not fully understood.

Purpose of the Study:

  • To investigate the thyroid status of infants identified with normal thyroxine (T4) and elevated thyroid-stimulating hormone (TSH) through newborn screening.
  • To determine if basal metabolic rate (BMR) can identify subclinical hypothyroidism in these infants.
  • To assess the response to thyroid therapy in infants with low BMR and hyperthyrotropinemia.

Main Methods:

Related Experiment Videos

  • Studied 10 infants (9-63 days old) with normal T4 and varying TSH levels using indirect calorimetry to measure basal metabolic rate (BMR).
  • Clinically assessed infants for euthyroid status and biochemical markers of hypothyroidism.
  • Monitored BMR and TSH levels before and after thyroid therapy.

Main Results:

  • Four infants had a low BMR (38.1 kcal/kg/day) and TSH levels >7.0 microU/mL; six infants had normal BMR (49.6 kcal/kg/day) and TSH levels <6.0 microU/mL.
  • Infants with low BMR showed normalization of BMR (48.7 kcal/kg/day) and TSH suppression (3.2 microU/mL) within 3 weeks of thyroid therapy, with sustained normal T4 levels.
  • These findings suggest a hypometabolic state in infants with normal T4 but elevated TSH.

Conclusions:

  • Basal metabolic rate (BMR) assessment is a valuable tool for identifying subclinical hypothyroidism in infants with normal thyroxine (T4) levels and elevated thyroid-stimulating hormone (TSH).
  • Monitoring BMR alongside TSH levels can aid in defining and managing this condition.
  • Thyroid replacement therapy effectively normalizes metabolic rate and TSH in these infants.