Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcineurin nephrotoxicity.

David Williams1, Lukas Haragsim

  • 1Department of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA.

Advances in Chronic Kidney Disease
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural repair by NT3-chitosan via enhancement of endogenous neurogenesis after adult focal aspiration brain injury.

Biomaterials·2017
Same author

<i>Pseudomonas aeruginosa</i> adaptation and diversification in the non-cystic fibrosis bronchiectasis lung.

The European respiratory journal·2017
Same author

Engagement of the medical-technology sector with society.

Science translational medicine·2017
Same author

A Nomogram for Calculation of Maximum Recommended Dose by Volume of Local Anesthetic in Pediatric Dentistry.

Pediatric dentistry·2017
Same author

Osteoporosis, obesity, and sarcopenia on abdominal CT: a review of epidemiology, diagnostic criteria, and management strategies for the reporting radiologist.

Abdominal radiology (New York)·2017
Same author

Chronic Granulomatous Disease Presenting as Aspergillus Fumigatus Pneumonia in a Previously Healthy Young Woman.

The American journal of case reports·2017
Same journal

The Physician Leader: Teaching Leadership in Medicine.

Advances in chronic kidney disease·2022
Same journal

Postgraduate Education and Training for the Nephrology Physician Assistants and Nurse Practitioners.

Advances in chronic kidney disease·2022
Same journal

Evaluation Evolution: Designing Optimal Evaluations to Enhance Learning in Nephrology Fellowship.

Advances in chronic kidney disease·2022
Same journal

Kidney Pathology Education for Nephrology Fellows: Past, Present, and Future.

Advances in chronic kidney disease·2022
Same journal

Clinician Educator Pathway for Nephrology Fellows: The University of North Carolina Experience.

Advances in chronic kidney disease·2022
Same journal

Current Trends and Challenges in Nephrology Fellowship Training: Expansion of Education in Home Dialysis, Palliative Care, and Point-of-Care Ultrasound.

Advances in chronic kidney disease·2022
See all related articles

Calcineurin inhibitors improve initial transplant survival but chronic nephrotoxicity hinders long-term kidney graft survival. This review covers calcineurin inhibitor nephrotoxicity in kidney transplantation.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Background:

  • Calcineurin inhibitors (cyclosporine, tacrolimus) enhance solid organ transplant survival.
  • These drugs reduce acute rejection in cadaveric allograft recipients.
  • Long-term kidney graft survival remains suboptimal despite improved initial outcomes.

Purpose of the Study:

  • To review the current understanding of calcineurin inhibitor nephrotoxicity.
  • To discuss the management strategies for calcineurin inhibitor nephrotoxicity in kidney transplant recipients.

Main Methods:

  • Literature review of calcineurin inhibitor nephrotoxicity.
  • Analysis of factors contributing to chronic allograft dysfunction.
  • Synthesis of current management approaches.

Related Experiment Videos

Main Results:

  • Chronic calcineurin inhibitor nephrotoxicity is a significant cause of chronic allograft dysfunction.
  • Both immunologic and nonimmunologic factors contribute to chronic allograft dysfunction.
  • Effective management strategies are crucial for improving long-term graft survival.

Conclusions:

  • While calcineurin inhibitors are vital for preventing acute rejection, their long-term nephrotoxic effects pose a challenge.
  • Addressing chronic calcineurin inhibitor nephrotoxicity is essential for enhancing long-term kidney allograft survival.
  • Further research and optimized management protocols are needed to mitigate calcineurin inhibitor-induced kidney damage.