Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular radiation effects and the bystander response.

John B Little1

  • 1Center for Radiation Sciences and Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. jlittle@hsph.harvard.edu

Mutation Research
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The MDM2/MDMX/p53 axis in the adaptive stress response.

Translational cancer research·2022
Same author

MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment.

Journal of molecular cell biology·2020
Same author

Response to the Letter by Colin Seymour and Carmel Mothersill.

Radiation research·2020
Same author

Functional interplay between p53 and Δ133p53 in adaptive stress response.

Cell death and differentiation·2019
Same author

MDMX under stress: the MDMX-MDM2 complex as stress signals hub.

Translational cancer research·2018
Same author

ZBTB7A governs estrogen receptor alpha expression in breast cancer.

Journal of molecular cell biology·2018

Recent research on the radiation-induced bystander effect reveals technological advances and the role of cell communication. Key questions remain regarding signaling, non-targeted effects, and radiation protection implications.

Area of Science:

  • Radiobiology
  • Cellular Biology
  • Radiation Oncology

Background:

  • The radiation-induced bystander effect describes biological responses in cells not directly hit by radiation.
  • Understanding this effect is crucial for accurate risk assessment and radiation protection strategies.

Purpose of the Study:

  • To review recent findings (past 2 years) enhancing the understanding of radiation-induced bystander effects.
  • To highlight technological advancements and key biological mechanisms involved.
  • To identify critical unanswered questions in the field.

Main Methods:

  • Literature review of studies published within the last two years.
  • Focus on technological advances, oxidative stress, cytoplasmic irradiation, and cell-to-cell communication.

Related Experiment Videos

  • Analysis of evidence for Connexin 43 mediated intercellular communication.

    • Main Results:

    • Technological progress has improved the study of bystander effects.
    • Oxidative stress and cytoplasmic irradiation play significant roles.
    • Cell-to-cell communication, particularly via Connexin 43, is a key mechanism induced by radiation exposure.

    Conclusions:

    • Recent findings have significantly advanced our understanding of the radiation-induced bystander effect.
    • Unanswered questions persist regarding intercellular signaling, non-targeted effects, potential benefits, and relevance to radiation protection.