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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
Published on: March 14, 2013
UPLC/MS for the identification of beta-blockers
Stephen A C Wren1, Pierre Tchelitcheff
1Analytical Development, PAR&D, AstraZeneca, Silk Business Park, Macclesfield, Cheshire SK10 2NA, UK. stephen.wren@astrazeneca.com
Journal of Pharmaceutical and Biomedical Analysis
|January 18, 2006
Abstract:
The beta-blockers Oxprenolol, Metoprolol, Acebutolol, Atenolol, Propranolol, Pindolol, and Alprenolol were analysed by both UPLC/MS and HPLC/MS using mobile phases containing acetonitrile, TFA and either H2O or D2O. UPLC gave superior separation performance and the quality of the mass spectra were at least as good as those from HPLC.
