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Safety of carbon bead injection for incontinence in patients taking warfarin

R J McCrery1, R A Appell

  • 1Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA.

Urology
|January 18, 2006
PubMed

Insights

Periurethral carbon bead injections using Durasphere can be safely administered to patients on warfarin anticoagulation. While minor complications like hematoma can occur, most patients tolerate the procedure without adverse events.

Area of Science:

  • Urology
  • Medical Device Safety

Background:

  • Urinary incontinence affects many women, with intrinsic sphincteric deficiency being a common cause.
  • Durasphere, a carbon-bead implant, is used for treating urinary incontinence.
  • Warfarin is a common anticoagulant requiring careful management during procedures.

Purpose of the Study:

  • To evaluate the safety and feasibility of Durasphere injections in patients on warfarin therapy.
  • To assess the risk of complications in patients receiving anticoagulation during periurethral injections.

Main Methods:

  • A case series of 20 patients with urinary incontinence undergoing periurethral carbon bead injections.
  • All procedures were performed under local anesthesia while patients were on therapeutic warfarin doses.
  • Complications related to anticoagulation were monitored and recorded.

Main Results:

  • 36 injections were performed in 20 patients receiving therapeutic warfarin.
  • Two complications occurred: a minor periurethral hematoma and a more severe case of urinary retention with intravesical hemorrhage.
  • Most procedures were completed without significant bleeding or anticoagulation-related issues.

Conclusions:

  • Periurethral carbon bead injections can be safely performed in most patients receiving therapeutic warfarin.
  • Careful patient selection and monitoring are essential.
  • Reversal of anticoagulation is generally not required for this procedure.
Abstract

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