Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Roles of glycodelin in modulating sperm function.

William S B Yeung1, Kai-Fai Lee, Riitta Koistinen

  • 1Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. wsbyeung@hkucc.hku.hk

Molecular and Cellular Endocrinology
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human chorionic gonadotropin alpha and beta levels are associated with maternal demographic characteristics and psychosocial measures of stress and discrimination.

Psychoneuroendocrinology·2026
Same author

Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst-endometrium interaction in humans.

Human reproduction (Oxford, England)·2026
Same author

Highlights of the FEBS3+ meeting Exploring molecular frontiers.

FEBS open bio·2026
Same author

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol-Driven WNT7B Suppression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen.

BMC biology·2025
Same author

Altered Glycosylation of PSA in Prostate Cancer Tissue.

The Prostate·2025
Same journal

Blood-based microRNAs as biomarkers of insulin resistance in childhood obesity: A systematic review and meta-analysis.

Molecular and cellular endocrinology·2026
Same journal

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology·2026
Same journal

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026
Same journal

G1 regulation of BK<sub>Ca</sub> channel leads to decreased migration of senescent pericytes and improved age-related hearing loss.

Molecular and cellular endocrinology·2026
Same journal

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity.

Molecular and cellular endocrinology·2026
Same journal

Retraction notice to " Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on phosphatidylinositol 3 kinase but not MAP kinase activation" [Mol. Endocrinol. 390 (2014) 26-33].

Molecular and cellular endocrinology·2026
See all related articles

Glycodelin, a glycoprotein, has isoforms that regulate sperm function. These molecules, including glycodelin-S, -A, and -F, play distinct roles in capacitation and fertilization success.

Area of Science:

  • Reproductive Biology
  • Glycobiology
  • Molecular Endocrinology

Background:

  • Glycodelin is a glycoprotein with three identified isoforms: glycodelin-S, glycodelin-A, and glycodelin-F.
  • These isoforms share a common protein core but differ in their carbohydrate structures.
  • Each isoform is found in distinct reproductive tract locations and possesses unique functions.

Purpose of the Study:

  • To elucidate the specific biological roles of different glycodelin isoforms on sperm function.
  • To understand the sequential actions of glycodelin isoforms in the context of fertilization.

Main Methods:

  • The study is based on existing literature and preliminary findings regarding glycodelin isoforms.
  • Analysis of the presence and functions of glycodelin-S, -A, and -F in human reproductive fluids.

Related Experiment Videos

  • Investigation of glycodelin's effects on sperm capacitation, zona pellucida binding, and acrosome reaction.

    • Main Results:

    • Glycodelin-S in seminal plasma suppresses sperm capacitation, maintaining sperm in an uncapacitated state.
    • Glycodelin-A, found in amniotic and uterine fluids, inhibits sperm-zona pellucida binding and may offer immune protection.
    • Glycodelin-F from follicular fluid also inhibits sperm-zona pellucida binding and prevents premature acrosome reaction.

    Conclusions:

    • Different glycodelin isoforms exert distinct regulatory effects on sperm physiology.
    • These isoforms act sequentially to facilitate successful fertilization.
    • Further research suggests a potential fifth isoform that may enhance sperm-zona pellucida binding.