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Papillary glioneuronal tumor.
Istvan Vajtai1, Andreas Kappeler, Anton Lukes
1Department of Clinical Pathology, University of Berne, Switzerland. istvanvajtai@yahoo.com
Pathology, Research and Practice
|January 18, 2006
Summary
Papillary glioneuronal tumors (PGNTs) are low-grade mixed glial-neuronal neoplasms. This case report details a 13-year-old boy with a temporal lobe PGNT, successfully resected with a favorable outcome.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
Background:
- Papillary glioneuronal tumor (PGNT) is a rare, low-grade mixed glial-neuronal neoplasm.
- Typically affects juvenile and young adult patients.
Observation:
- A 13-year-old boy presented with headaches and a seizure.
- MRI revealed a left temporal lobe PGNT with a cyst-mural nodule configuration.
- Gross total resection was achieved, with an uneventful recovery.
Findings:
- Histology confirmed a biphasic mixture of synaptophysin- and GFAP-positive cells.
- Tumor cells expressed non-polysialylated NCAM-L.
- Low MIB-1 labeling index (<1%) and absence of anaplastic features were noted.
Implications:
- PGNT is considered a distinct entity within extraventricular neurocytic neoplasia.
- The characteristic presentation aids in diagnosis and management.
- Further research into PGNT classification and behavior is warranted.