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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine
Wim Derave1, Els Vanden Eede, Peter Hespel
1Research Unit of Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium. wim.derave@ugent.be
Objective:
Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine.
Methods:
We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans.
Results And Conclusion:
Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.
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