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Related Experiment Videos

Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study.

Ragy R Girgis1, Vaibhav A Diwadkar, Jeffrey J Nutche

  • 1Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA.

Schizophrenia Research
|January 18, 2006
PubMed
Summary

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Risperidone, an atypical antipsychotic, may alter brain structure in individuals with first-episode psychosis. This study observed short-term changes in grey and white matter following risperidone treatment.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Atypical antipsychotics, such as risperidone, are increasingly recognized for potential neuroplastic effects.
  • Understanding the short-term impact of these medications on brain structure is crucial for managing early psychosis.

Purpose of the Study:

  • To investigate the immediate effects of risperidone on brain parenchyma in neuroleptic-naïve individuals with first-episode psychosis.
  • To compare brain structural changes between patients treated with risperidone and healthy controls.

Main Methods:

  • Voxel-based morphometry (VBM) was employed to analyze MRI scans.
  • Baseline and 6-week follow-up MRI scans were acquired from 15 first-episode psychosis patients and 15 healthy controls.
  • Participants were treated with risperidone.

Related Experiment Videos

Main Results:

  • Risperidone-treated subjects showed significant changes in grey and white matter volumes.
  • Observed alterations were noted in regions including the superior temporal gyrus.
  • No significant structural changes were detected in the control group.

Conclusions:

  • This exploratory study suggests that risperidone may induce short-term structural changes in the brain parenchyma of individuals experiencing their first episode of psychosis.
  • Further research is warranted to elucidate the clinical implications of these findings.