Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multifunctionality of human 17beta-hydroxysteroid dehydrogenases.

Gabriele Moeller1, Jerzy Adamski

  • 1GSF-National Research Center of Environment and Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany. gabriele.moeller@gsf.de

Molecular and Cellular Endocrinology
|January 18, 2006
PubMed
Summary

17Beta-hydroxysteroid dehydrogenases (17beta-HSDs), initially identified by steroid activity, exhibit broader substrate specificity. This review explores their potential roles beyond steroid metabolism in fundamental metabolic pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hnrnpa1 is essential for early zebrafish development and lipid metabolism: insights from a novel zebrafish knockout model.

Frontiers in cell and developmental biology·2026
Same author

Acylcarnitines and prediction of renal function decline in type 2 diabetes.

BMJ open diabetes research & care·2026
Same author

Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.

Redox biology·2026
Same author

Serum metabolite patterns of adipose tissue distribution and body composition subphenotypes.

Lipids in health and disease·2026
Same author

A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.

Metabolism: clinical and experimental·2026
Same author

Urea cycle modulation by combined SGLT2 inhibitors and metformin.

BMC medicine·2026

Area of Science:

  • Biochemistry
  • Enzymology
  • Molecular Biology

Background:

  • 17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) are enzymes belonging to short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs) superfamilies.
  • Enzymes were initially named based on their steroid substrate activity or sequence similarity to other 17beta-HSDs.

Purpose of the Study:

  • To review the broader substrate specificity of 17beta-HSDs.
  • To discuss the potential multifunctionality of these enzymes beyond steroid metabolism.
  • To explore their roles in basic metabolic pathways.

Main Methods:

  • Literature review of existing studies on 17beta-HSDs.
  • Analysis of enzyme characterization data.
  • Discussion of in vivo functional implications.

Related Experiment Videos

Main Results:

  • 17beta-HSDs demonstrate a wider range of substrates than initially characterized.
  • Key in vivo functions may lie in general metabolic pathways rather than solely steroid metabolism.
  • Evidence suggests significant overlap in function and substrate specificity among different 17beta-HSDs.

Conclusions:

  • The substrate specificity of 17beta-HSDs is broader than previously understood.
  • These enzymes likely play crucial roles in fundamental metabolic processes.
  • Understanding their multifunctionality is essential for comprehending their overall biological significance.