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Plasmablastic lymphoma: a clinicopathologic correlation.

Gretchen S Folk1, Susan L Abbondanzo, Esther L Childers

  • 1Department of Oral and Maxillofacial Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. gsfolk@nmcsd.med.navy.mil

Annals of Diagnostic Pathology
|January 18, 2006
PubMed
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Plasmablastic lymphoma (PBL) is an aggressive B-cell lymphoma often presenting in the oral cavity, frequently associated with HIV infection. This rare lymphoma may be challenging for pathologists due to its unusual presentation and immunophenotype.

Area of Science:

  • Oncology
  • Pathology
  • Immunology

Background:

  • Plasmablastic lymphoma (PBL) is a rare, aggressive B-cell neoplasm.
  • PBL characteristically presents extranodally, particularly in the oral cavity.
  • Association with human immunodeficiency virus (HIV) infection is common, but not exclusive.

Observation:

  • Five cases of oral cavity lymphomas meeting WHO criteria for PBL were analyzed.
  • Immunohistochemistry revealed plasma cell differentiation markers (CD38 and/or CD138) in all cases.
  • Expression of B-cell markers (CD20, CD79a) was limited; HHV8 and EBV-LMP-1 were negative.

Findings:

  • PBL demonstrates aggressive behavior with poor prognosis, as evidenced by limited survival in the studied cases.
  • Immunophenotypic analysis confirmed plasma cell differentiation, distinguishing it from other B-cell lymphomas.

Related Experiment Videos

  • The study highlights the diagnostic challenges posed by PBL's unusual features and extranodal presentation.

    • Implications:

    • Accurate diagnosis of oral cavity PBL is crucial for appropriate patient management.
    • Understanding PBL's immunophenotype aids in differentiating it from other oral lymphomas.
    • Further research is needed to improve outcomes for patients with this aggressive lymphoma.