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Detection of TLS/FUS-CHOP fusion transcripts in a case of oral liposarcoma
Elena Riet Correa Rivero1, Ricardo Alves Mesquita, Suzana Cantanhede Orsini Machado de Sousa
1Department of Oral Pathology, School of Dentistry, University of São Paulo, 05508-900 São Paulo, Brazil.
Objective:
The aim of this study was to detect the chromosomal translocation t(12;16)(q13;p11) that leads to a gene fusion encoding a FUS-CHOP chimeric protein and has been shown to be highly characteristic of myxoid and round cell subtypes of liposarcoma, in a case of oral myxoid liposarcoma.
Method And Materials:
Nested reverse transcriptase-polymerase chain reaction to detect the TLS/FUS-CHOP fusion gene transcript was performed. A case of inflammatory fibrous hyperplasia and a case of oral lipoma were included as negative controls.
Results:
Only the myxoid oral liposarcoma showed a 103-base pair product, specific of TLS/FUS-CHOP fusion type II transcript.
Conclusion:
The identification of FUS-CHOP transcript is potentially useful in the diagnosis and research of oral liposarcomas.
