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Related Experiment Videos

Levofloxacin interactions with essential and trace elements.

Najma Sultana1, M Saeed Arayne, Safila Sharif

  • 1Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi.

Pakistan Journal of Pharmaceutical Sciences
|January 18, 2006
PubMed
Summary
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Metal ions significantly reduce the release of the antibiotic levofloxacin. This interaction impacts the drug

Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Analytical Chemistry

Background:

  • Levofloxacin is a widely used fluoroquinolone antibiotic.
  • Its efficacy relies on proper absorption and bioavailability.
  • Interactions with metal ions can affect drug availability.

Purpose of the Study:

  • To investigate the in vitro release of levofloxacin.
  • To determine the effect of various metal ions on levofloxacin release.
  • To assess these effects under different physiological pH conditions.

Main Methods:

  • Levofloxacin release studies were conducted using a BP 2002 dissolution test apparatus.
  • Experiments were performed at 37°C in simulated gastric juice, simulated intestinal juice, and at blood pH.

Related Experiment Videos

  • The influence of magnesium, calcium, chromium, manganese, ferric, ferrous, cobalt, nickel, copper, zinc, and cadmium ions was evaluated.

    • Main Results:

    • The in vitro release of levofloxacin was significantly retarded in the presence of all tested metal ions.
    • This inhibitory effect was observed across simulated gastric, intestinal, and blood pH conditions.
    • Specific metal ions demonstrated varying degrees of retardation on levofloxacin dissolution.

    Conclusions:

    • Metal ions can form complexes with levofloxacin, hindering its dissolution and release.
    • The presence of common metal ions may reduce the bioavailability of levofloxacin.
    • Clinical implications regarding co-administration with metal-containing supplements or antacids should be considered.