Stability-indicating assay of sulphacetamide in thermally degraded solutions

A stability-indicating assay method for the determination of sulphacetamide in thermally degraded solutions is reported. The method is based on the difference in the absorption maxima of sulphacetamide and sulphanilamide at pH 4.0 and their simultaneous determination by a two component assay using the analytical wavelengths of 258 nm and 268 nm the reproducibility of the method lies within +/- 4%. It is rapid and specific for the assay of sulphacetamide in degraded opthalmic preparations.