Related Experiment Videos
Photo-oxidation of sulphanilamide to blue product
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Abstract:
Aqueous solutions of sulphanilamide undergo photolysis to produce several compounds including the blue oxidation product. The kinetics of the reaction leading to blue product has been studied and the apparent first-order rate constants for the formation of blue product at pH 1-11 have been calculated. Effect of certain antioxidants on this reaction at pH 7.0 and rates of inhibition have been determined. Ascorbic acid has been found to completely inhibit the formation of blue product. A reaction pathway for the photo-oxidation of sulphanilamide to blue product has been suggested. The blue product has been shown (James, 1940) to possess much higher antibacterial activity than sulphanilamide.
Related Concept Videos
Biosynthesis in Bacteria
Biosynthesis of Polysaccharides
Amino Acid Biosynthetic Pathways
Bioreactor Controls-III
Production of Antibiotics