Related Experiment Videos
Studies on marine algae for haemagglutinic activity
1Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Pakistan Journal of Pharmaceutical Sciences
|July 1, 1994
Summary
Marine algae from Karachi coasts were screened for agglutinic activity. Several red algae species, including Gelidium usmanghani, showed significant haemagglutinic activity, indicating potential for medical applications.
Area of Science:
- Marine Biology
- Biotechnology
- Immunology
Background:
- Lectins (agglutinins) possess significant medical and immunological applications.
- Phytohaemagglutinins derived from plants are valuable in blood banking procedures.
Purpose of the Study:
- To screen marine algae from the Karachi coastal region for haemagglutinic activity.
- To identify specific algal species with potential applications in blood banking and medical diagnostics.
Main Methods:
- Collected 53 marine algal samples from the Karachi coast.
- Performed extraction, fractionation, serial dilution, and titre determinations.
- Tested haemagglutinic activity against human erythrocytes of blood groups A, B, AB, and O.
Main Results:
- Screened 44 algal samples, with 14 (Chlorophyta), 13 (Phaeophyta), and 17 (Rhodophyta).
- Rhodophyta (red algae) exhibited the highest incidence of haemagglutinic activity.
- Significant activity (titre 2(3)) observed in Valoniopsis pachynema (green), Colpomenia sinuosa (brown), and four red algae species: Gelidium usmanghani, Gracilaria foliifera, Hypnea pannosa, and Hynea valentiae.
Conclusions:
- Marine algae, particularly from the Rhodophyta division, are a promising source of haemagglutinins.
- Identified algal species demonstrate significant potential for use in blood banking and immunological assays.
- Findings align with existing literature on algal lectins and their bioactivities.