Synthesis and anti-microbial screening of some piperidine derivatives

Synthesis of piperidine derivatives viz, 1-(4'-methoxy phenacyl)-N-methyl piperidinium bromide, and 1-(4'-nitrophenacyl)-N-methyl piperidinium bromide, and 1-(3', 4'-dihydroxy phenacyl)-N-methyl piperidinium chloride was carried out by quarternizing N-methyl piperidine with corresponding phenacyl halides. The structures of these compounds were elucidated by spectroscopic techniques such as UV, IR, EI mass and 1H-NMR. The compounds were subjected to antimicrobial screening in quantities of 10 mg/ml dissolved in DMSO. Disc diffusion method was used to observe the significance of these compounds against seven bacterial and one fungal cultures.