Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet Activating Factor antagonists.

S Afroz1, A Ara, M Arif

  • 1Department of Pharmacology, University of Karachi, Karachi.

Pakistan Journal of Pharmaceutical Sciences
|January 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Pr<sub>2</sub>O<sub>3</sub> addition on the mechanical properties of the mullite/ZTA composites.

Scientific reports·2026
Same author

Profile of Respiratory Tract Aspergillus Infection among Clinically Suspected Pulmonary Tuberculosis Cases in a Tertiary Care Hospital.

Mymensingh medical journal : MMJ·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

INVESTIGATING FACTORS INFLUENCING THE AMOUNT OF INJECTION PAIN IN THE ORAL CAVITY: A SYSTEMATIC REVIEW.

Georgian medical news·2025
Same author

Airway events in pregnant patients with morbid obesity undergoing caesarean delivery under general anaesthesia: a retrospective cohort study (2015-2024).

International journal of obstetric anesthesia·2025
Same author

The effects of saturated fatty acid supplements on plasma and milk concentration of fatty acid esters of hydroxy fatty acids in dairy cows.

JDS communications·2025
Same journal

Differential effects of sevoflurane versus propofol on calmodulin expression in breast cancer patients.

Pakistan journal of pharmaceutical sciences·2026
Same journal

Neoadjuvant nivolumab plus chemotherapy in resectable NSCLC: A pharmacological outcome study.

Pakistan journal of pharmaceutical sciences·2026
Same journal

Long-term clinical outcomes of paclitaxel-coated balloon angioplasty in chronic deep vein thrombosis: A multicenter retrospective study.

Pakistan journal of pharmaceutical sciences·2026
Same journal

The hybrid drug delivery system of TCPP-Co, β-cyclodextrin and piroxicam: Spectroscopic characterization, morphological reorganization and controlled release dynamics.

Pakistan journal of pharmaceutical sciences·2026
Same journal

Stability of serum cytokeratin 18-M30 under different storage conditions for drug-induced liver injury assessment.

Pakistan journal of pharmaceutical sciences·2026
Same journal

The effect and factor analysis of potassium sodium hydrogen citrate on the formation of double J tube wall stones after ureteral stone surgery.

Pakistan journal of pharmaceutical sciences·2026
See all related articles

Platelet Activating Factor (PAF) is a key inflammatory mediator. Researchers are developing PAF antagonists to treat inflammatory diseases like asthma and sepsis.

Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Platelet Activating Factor (PAF) is a potent endogenous inflammatory mediator derived from D-glycerol phospholipids.
  • PAF interacts with G-protein coupled receptors on inflammatory cells, causing increased vascular permeability, hypotension, bronchoconstriction, and cell aggregation.
  • These effects link PAF to inflammatory conditions such as septic shock and asthma.

Purpose of the Study:

  • To explore the discovery of agents that block PAF's action at its receptor.
  • To review the diverse structural classes of identified PAF antagonists.
  • To discuss the progression of PAF antagonists in clinical evaluation for various disorders.

Main Methods:

  • Review of existing literature on PAF antagonists.

Related Experiment Videos

  • Analysis of traditional medicinal chemistry approaches in drug discovery.
  • Examination of clinical trial outcomes for PAF antagonists.

    • Main Results:

    • A wide range of PAF antagonists, including analogs, natural products, and synthetic compounds, have been identified.
    • Several PAF antagonists have advanced to clinical trials for conditions like sepsis and pancreatitis.
    • Early PAF antagonists showed efficacy in animal asthma models but failed in human trials.

    Conclusions:

    • PAF antagonists represent a significant area of research for managing inflammatory diseases.
    • Despite challenges, ongoing development targets conditions such as sepsis and pancreatitis.
    • Further research may benefit from sophisticated molecular models of the PAF receptor.