Antibacterial studies of cefixime copper, zinc and cadmium complexes

Antibacterial studies of metal complexes of cefixime, with copper zinc and cadmium have been carried out by observing the Minimum Inhibitory Concentration (MIC) and by measuring the Zone of Inhibition of the complexes and compared with the parent cephalosporin against both Gram negative and Gram positive microorganisms. Various microorganisms used were Staphylococcus aureus, E. coli, Klebsiella and Proteus species. For MIC observation, serial dilution method was employed and zone sizes were determined by diffusion disk method. Our investigations divulge that formation of complexes results in decrease in antimicrobial activity of cefixime and MIC values were increased.